Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.30 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.30 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL544720 | 0.83 | TDP1 (0.48) | TDP1OR51E2TP53TSHRMAPT | |
| Glycerin SCHEMBL7727938 | 0.82 | LMNA (0.47) | OR51E2MEN1KMT2A | |
| Propylene Glycol SCHEMBL27607477 | 0.81 | TDP1 (0.46) | TDP1OR51E2TP53TSHRMAPT | |
| SCHEMBL16564611 | 0.80 | TP53 (0.41) | TP53TSHRMEN1KMT2ACHRM2 | |
| SCHEMBL587365 | 0.80 | — | — | |
| Propylene Glycol SCHEMBL28486853 | 0.79 | TDP1 (0.56) | TDP1OR51E2TP53TSHR | |
| Propylene Glycol SCHEMBL28574117 | 0.79 | TDP1 (0.56) | TDP1OR51E2TP53TSHR | |
| Propylene Glycol SCHEMBL2362816 | 0.79 | TDP1 (0.56) | TDP1OR51E2TP53TSHRMME | |
| Alcohol SCHEMBL9255774 | 0.78 | ALDH1A1 (0.40) | TSHRHSD17B10 | |
| Methyl Alcohol SCHEMBL1326721 | 0.78 | ALDH1A1 (0.38) | TDP1TP53TSHRHSD17B10CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1050055-A2 | A POWER TRANSFORMER/REACTOR | ABB AB (SE) | 2000-11-08 | — | — | EP | claimed |
| WO-1999028927-A2 | A POWER TRANSFORMER/REACTOR | ABB AB (SE) | 1999-06-10 | — | — | WO | claimed |
| WO-2023093468-A1 | WATER CONTENT AND DENSE STATE REGULATION AND CONTROL METHOD BASED ON WEATHER-RESISTANT HYDROGEL ROADBED OPERATION PERIOD | 山东交通学院 | 2023-06-01 | — | — | WO | disclosed |
| CN-114032723-B | Method for regulating and controlling water content and compact state of roadbed based on weather-resistant hydrogel in operation period | 山东大学 | 2022-08-19 | — | — | CN | disclosed |
| CN-114032723-A | Method for regulating and controlling water content and compact state of roadbed based on weather-resistant hydrogel in operation period | 山东大学 | 2022-02-11 | — | — | CN | disclosed |