Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13516529 | 0.81 | SMN1; SMN2 (0.40) | SMN1; SMN2NAPRTMEN1GAAKMT2A | |
| SCHEMBL6681570 | 0.80 | MEN1 (0.61) | SMN1; SMN2MEN1GAAKMT2AKDM4E | |
| SCHEMBL8105262 | 0.76 | ALDH1A1 (0.53) | SMN1; SMN2MEN1GAAKMT2AKDM4E | |
| SCHEMBL16504573 | 0.75 | PDE5A (0.41) | SMN1; SMN2NAPRTMEN1GAAKMT2A | |
| SCHEMBL18989970 | 0.75 | NAPRT (0.42) | NAPRTKMT2AHDAC1SHMT2KDM4E | |
| SCHEMBL783597 | 0.71 | KMT2A (0.63) | SMN1; SMN2NAPRTMEN1GAAKMT2A | |
| SCHEMBL27446646 | 0.67 | SMN1; SMN2 (0.49) | SMN1; SMN2 | |
| SCHEMBL21933011 | 0.67 | CYP1A2 (0.45) | SMN1; SMN2MEN1GAAKMT2ACYP1A2 | |
| SCHEMBL13085735 | 0.67 | NOS3 (0.43) | SMN1; SMN2MEN1KMT2AKDM4ECYP1A2 | |
| SCHEMBL16771464 | 0.67 | NR4A2 (0.38) | SMN1; SMN2NAPRTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117885-A | Biphenyl-substituted quinoline derivatives | E. R. SQUIBB & SONS, INC. (US) | 2000-09-12 | — | — | US | disclosed |
| EP-0556060-A1 | Biphenyl-substituted quinoline and naphthyridines derivatives as angiotensine II antagonists | E.R. SQUIBB & SONS, INC. (US) | 1993-08-18 | — | — | EP | disclosed |