SCHEMBL8091283

SCHEMBL8091283

CC(Cc1ccccc1)NCc1ccc(Cl)cc1

nearest known ligand 0.79

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 8/20 0.79
LMNA P02545 1/20 0.64
CYP1A2 P05177 2/20 0.55
CYP2D6 P10635 2/20 0.55
CYP2C19 P33261 1/20 0.55
POLB P06746 1/20 0.54
MAPK1 P28482 1/20 0.54
CYP3A4 P08684 1/20 0.53
TSHR P16473 1/20 0.53
TAAR1 Q96RJ0 2/20 0.52
SLC18A2 Q05940 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8615786 0.93 SIGMAR1 (0.69) SIGMAR1LMNACYP1A2CYP2D6CYP2C19
N-Benzylamphetamine SCHEMBL2795222 0.89 SIGMAR1 (1.00) SIGMAR1LMNACYP1A2CYP2D6POLB
N-Benzylamphetamine SCHEMBL2451256 0.89 SIGMAR1 (1.00) SIGMAR1LMNACYP1A2CYP2D6POLB
N-Benzylamphetamine SCHEMBL2798189 0.89 SIGMAR1 (1.00) SIGMAR1LMNACYP1A2CYP2D6POLB
N-Benzylamphetamine SCHEMBL8085021 0.87 SIGMAR1 (0.96) SIGMAR1LMNACYP1A2CYP2D6POLB
SCHEMBL24997843 0.86 SIGMAR1 (0.79) SIGMAR1LMNACYP1A2CYP2D6POLB
SCHEMBL606189 0.86 SIGMAR1 (0.85) SIGMAR1LMNACYP1A2CYP2D6POLB
SCHEMBL608555 0.84 SIGMAR1 (0.82) SIGMAR1LMNACYP1A2CYP2D6POLB
SCHEMBL8092729 0.84 SIGMAR1 (0.82) SIGMAR1LMNACYP1A2CYP2D6POLB
SCHEMBL3235181 0.83 SIGMAR1 (0.79) SIGMAR1LMNACYP1A2CYP2D6POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
EP-0507863-A4 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF 1993-07-07 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed
EP-0507863-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1992-10-14 EP disclosed
WO-1991009594-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1991-07-11 WO disclosed