Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 7/20 | 0.58 |
| ▸ | CA2 | P00918 | 7/20 | 0.58 |
| ▸ | CA7 | P43166 | 7/20 | 0.58 |
| ▸ | CA9 | Q16790 | 7/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.53 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | CASR | P41180 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091389 | 0.84 | EPHX1 (0.58) | CA1CA2CA9LMNAMAPT | |
| SCHEMBL8091387 | 0.80 | KDR (0.68) | KDRCA1CA2CA7CA9 | |
| SCHEMBL118026 | 0.80 | KDR (1.00) | KDRCA1CA2CA7CA9 | |
| SCHEMBL29364392 | 0.80 | KDR (1.00) | KDRCA1CA2CA7CA9 | |
| SCHEMBL14684324 | 0.79 | KDR (0.75) | KDRCA1CA2CA7CA9 | |
| SCHEMBL8091423 | 0.77 | ALDH1A1 (0.53) | CA1CA2CA7CA9LMNA | |
| SCHEMBL12413876 | 0.77 | KDR (0.82) | KDRCA1CA2CA7CA9 | |
| SCHEMBL12310641 | 0.77 | KDR (0.76) | KDRCA1CA2CA7CA9 | |
| SCHEMBL2600217 | 0.76 | KDR (0.69) | KDRPDK1LMNATP53MAPT | |
| SCHEMBL11005058 | 0.76 | KDR (0.85) | KDRCA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147115-A | SULFONYLUREIDO-4-HALOBENZENE DERIVATIVES; ANTICARCINOGENIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0467621-B1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | LILLY CO ELI (US) | 1994-06-15 | — | — | EP | disclosed |
| US-5216026-A | Administering to the mammal N-1-butanesulfonamide derivatives and salts | ELI LILLY AND COMPANY (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0467621-A1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |