Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 4/20 | 0.42 |
| ▸ | TK1 | P04183 | 3/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL887851 | 0.97 | TK1 (0.43) | TK1ALBPKM | |
| Phosphoric Acid SCHEMBL5191067 | 0.93 | TYMP (0.42) | TYMPTK1 | |
| SCHEMBL27655076 | 0.90 | TYMP (0.44) | TYMPTK1ALBPKM | |
| SCHEMBL14388585 | 0.90 | TYMP (0.44) | TYMPTK1ALBPKM | |
| Phosphoric Acid SCHEMBL5285296 | 0.89 | TYMP (0.39) | TYMPTK1 | |
| SCHEMBL27436150 | 0.89 | TK1 (0.43) | TYMPTK1ALBPKM | |
| SCHEMBL14388593 | 0.89 | TK1 (0.43) | TYMPTK1ALBPKM | |
| SCHEMBL1517629 | 0.88 | TK1 (0.44) | TK1ALBPKM | |
| SCHEMBL28249854 | 0.87 | TK1 (0.42) | TK1ALBPKM | |
| Phosphoric Acid SCHEMBL7240883 | 0.86 | TYMP (0.43) | TYMPTK1ALBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0866796-B1 | IMPROVEMENTS IN OR RELATING TO MUTAGENESIS OF NUCLEIC ACIDS | AMERSHAM PHARM BIOTECH UK LTD (GB) | 2000-11-29 | — | — | EP | claimed |
| EP-0866796-A1 | IMPROVEMENTS IN OR RELATING TO MUTAGENESIS OF NUCLEIC ACIDS | MEDICAL RESEARCH COUNCIL (GB) | 1998-09-30 | — | — | EP | claimed |
| WO-1997011083-A1 | IMPROVEMENTS IN OR RELATING TO MUTAGENESIS OF NUCLEIC ACIDS | MEDICAL RESEARCH COUNCIL (GB) | 1997-03-27 | — | — | WO | claimed |
| EP-0866796-B1 | IMPROVEMENTS IN OR RELATING TO MUTAGENESIS OF NUCLEIC ACIDS | AMERSHAM PHARM BIOTECH UK LTD (GB) | 2000-11-29 | — | — | EP | disclosed |
| EP-0866796-A1 | IMPROVEMENTS IN OR RELATING TO MUTAGENESIS OF NUCLEIC ACIDS | MEDICAL RESEARCH COUNCIL (GB) | 1998-09-30 | — | — | EP | disclosed |
| WO-1997011083-A1 | IMPROVEMENTS IN OR RELATING TO MUTAGENESIS OF NUCLEIC ACIDS | MEDICAL RESEARCH COUNCIL (GB) | 1997-03-27 | — | — | WO | disclosed |