Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMP | P19971 | 4/20 | 0.43 |
| ▸ | TK1 | P04183 | 3/20 | 0.41 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL7243142 | 1.00 | TYMP (0.43) | TYMPTK1ALBPKMLMNA | |
| SCHEMBL135210 | 0.95 | TK1 (0.44) | TK1ALBPKMLMNABLM | |
| SCHEMBL16187026 | 0.95 | TK1 (0.44) | TK1ALBPKMLMNABLM | |
| SCHEMBL13253917 | 0.86 | ALDH1A1 (0.42) | TK1 | |
| SCHEMBL7243147 | 0.86 | TK1 (0.51) | TK1 | |
| Phosphoric Acid SCHEMBL8091428 | 0.86 | TYMP (0.42) | TYMPTK1ALBPKM | |
| Phosphoric Acid SCHEMBL5191067 | 0.85 | TYMP (0.42) | TYMPTK1 | |
| SCHEMBL19387606 | 0.83 | TK1 (0.44) | TK1LMNABLMPMP22TSHR | |
| SCHEMBL14388585 | 0.83 | TYMP (0.44) | TYMPTK1ALBPKMLMNA | |
| SCHEMBL9796854 | 0.83 | TK1 (0.45) | TYMPTK1ALBPKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531476-B1 | Block multiplication of virus within body and restore immune functions by virtue of inhibitory activity toward platelet activating factor | UNIVERSITE PARIS 7 - DENIS DIDEROT (FR) | 2003-03-11 | — | — | US | disclosed |
| EP-1095029-B1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIV PARIS 7 DENIS DIDEROT (FR) | 2002-09-18 | — | — | EP | disclosed |
| EP-1095029-A1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIVERSITE PARIS 7 - Denis DIDEROT (FR) | 2001-05-02 | — | — | EP | disclosed |
| WO-2000001677-A1 | PIPERAZINE DERIVATIVES INHIBITING HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | UNIVERSITE PARIS 7 - DENIS DIDEROT (FR) | 2000-01-13 | — | — | WO | disclosed |