Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.80 |
| ▸ | MAPT | P10636 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | HTR1A | P08908 | 5/20 | 0.72 |
| ▸ | HTR7 | P34969 | 4/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | GRM5 | P41594 | 1/20 | 0.68 |
| ▸ | ME2 | P23368 | 1/20 | 0.66 |
| ▸ | ME1 | P48163 | 1/20 | 0.66 |
| ▸ | ME3 | Q16798 | 1/20 | 0.66 |
| ▸ | GFER | P55789 | 1/20 | 0.64 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16501806 | 0.94 | MEN1 (0.78) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3796071 | 0.89 | MAPT (0.80) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4907919 | 0.88 | MEN1 (0.65) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2824683 | 0.86 | MAPT (1.00) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL2820899 | 0.86 | KMT2A (0.74) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3791872 | 0.86 | GFER (0.74) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL4352910 | 0.83 | MEN1 (0.79) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3799394 | 0.83 | GFER (0.74) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL9320601 | 0.82 | MEN1 (0.68) | MEN1KMT2AALDH1A1SMN1; SMN2HTR1A | |
| SCHEMBL7258453 | 0.82 | ME2 (0.57) | MEN1KMT2AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | disclosed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | disclosed |