Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 9/20 | 0.38 |
| ▸ | HTT | P42858 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | GART | P22102 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090611 | 0.87 | SERPINE1 (0.55) | SERPINE1MAPTHTTALDH1A1MEN1 | |
| SCHEMBL8123179 | 0.86 | SERPINE1 (0.54) | SERPINE1CA1MMP2CA14MAPT | |
| SCHEMBL8091853 | 0.78 | SERPINE1 (0.52) | SERPINE1MAPTHTTALDH1A1MEN1 | |
| SCHEMBL8200499 | 0.78 | ALDH1A1 (0.55) | MAPTHTTALDH1A1MEN1KMT2A | |
| SCHEMBL8043013 | 0.77 | MAPK1 (0.41) | SERPINE1MAPTHTTALDH1A1MEN1 | |
| SCHEMBL7354885 | 0.77 | KMT2A (0.58) | SERPINE1MAPTHTTALDH1A1MEN1 | |
| SCHEMBL8091742 | 0.77 | SERPINE1 (0.52) | SERPINE1MAPTHTTALDH1A1MEN1 | |
| SCHEMBL27498000 | 0.77 | SERPINE1 (0.36) | SERPINE1CA1MMP2CA14MAPT | |
| SCHEMBL8091902 | 0.77 | SERPINE1 (0.49) | SERPINE1MAPTHTTALDH1A1MEN1 | |
| SCHEMBL8090680 | 0.77 | SERPINE1 (0.47) | SERPINE1MAPTHTTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136805-A | Quinoxaline dione derivatives, their production and their use in medicaments | SCNERING AKTIENGESELLSCHAFT (DE) | 2000-10-24 | — | — | US | disclosed |
| EP-0828746-A1 | NOVEL QUINOXALINE DIONE DERIVATIVES, THEIR PRODUCTION AND THEIR USE IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-03-18 | — | — | EP | disclosed |
| WO-1996037500-A1 | NOVEL QUINOXALINE DIONE DERIVATIVES, THEIR PRODUCTION AND THEIR USE IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-11-28 | — | — | WO | disclosed |