Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 8/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | ATR | Q13535 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090668 | 0.84 | PIK3CA (0.35) | PIK3CAPIK3CBMAPK1PIK3R1RAF1 | |
| SCHEMBL8098306 | 0.84 | CA12 (0.42) | PIK3CAPIK3CDMTOR | |
| SCHEMBL8090674 | 0.82 | PIK3CA (0.35) | PIK3CAPIK3CBMAPK1PIK3R1ATR | |
| SCHEMBL8090573 | 0.81 | PIK3CA (0.40) | PIK3CAPIK3CBPIK3R1ABL1PIK3CD | |
| SCHEMBL8099109 | 0.81 | CA12 (0.43) | PIK3CD | |
| SCHEMBL3926241 | 0.80 | ATR (0.53) | PIK3CAPIK3CBPIK3R1ATRPIK3CD | |
| SCHEMBL8099411 | 0.80 | CA12 (0.44) | PIK3CD | |
| SCHEMBL8211486 | 0.78 | PIK3CA (0.39) | PIK3CAPIK3CBMAPK1PIK3R1ATR | |
| SCHEMBL8091695 | 0.76 | CA12 (0.41) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL8081909 | 0.74 | CA12 (0.41) | PIK3CAPIK3CBPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |