Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8219536 | 0.84 | PIK3CA (0.45) | PIK3CAPIK3CBPIK3CDPIK3R1PIK3CG | |
| SCHEMBL8222565 | 0.83 | FPR1 (0.36) | PIK3CAPIK3CDPIK3R1HDAC3HDAC1 | |
| SCHEMBL8211453 | 0.81 | CYP3A4 (0.47) | PIK3CAPIK3CDCYP2C9CYP3A4CYP2D6 | |
| SCHEMBL3592500 | 0.79 | PIK3CA (0.62) | PIK3CAPIK3CDPIK3R1MTORATR | |
| SCHEMBL8213300 | 0.78 | PIK3CD (0.49) | PIK3CAPIK3CDMTORCYP2C9CYP3A4 | |
| SCHEMBL8091877 | 0.78 | PIK3CA (0.39) | PIK3CAPIK3CBMAPK1PIK3CDPIK3R1 | |
| SCHEMBL8212629 | 0.75 | PIK3R1 (0.43) | PIK3CAPIK3R1 | |
| SCHEMBL8213772 | 0.73 | PIK3CD (0.38) | PIK3CAPIK3CD | |
| SCHEMBL8218995 | 0.73 | CYP3A4 (0.47) | CYP2C9CYP3A4CYP2D6CYP2C19 | |
| SCHEMBL8216527 | 0.73 | PIK3CD (0.37) | PIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |