Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 11/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099954 | 0.91 | ABL1 (0.40) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8098812 | 0.88 | NPC1 (0.43) | RORCSMN1; SMN2CA12CA1CA2 | |
| SCHEMBL8099578 | 0.85 | PIK3CA (0.40) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8091877 | 0.81 | PIK3CA (0.39) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL3927202 | 0.81 | MTOR (0.46) | PIK3CAPIK3CDPIK3CBMTORPIK3CG | |
| SCHEMBL8093179 | 0.79 | RAB9A (0.42) | PIK3CAMTORGAASMN1; SMN2CA12 | |
| SCHEMBL8092946 | 0.79 | ABL1 (0.41) | PIK3CARORCPIK3R1PSEN1PSEN2 | |
| SCHEMBL8099405 | 0.78 | EPHX1 (0.42) | PIK3CAMTORRORCLMNAGAA | |
| SCHEMBL8099487 | 0.78 | CA12 (0.42) | GAASMN1; SMN2CA12CA1CA2 | |
| SCHEMBL8083200 | 0.76 | ALDH1A1 (0.43) | PIK3CAMTORPIK3CGPIK3R1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |