Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | FEN1 | P39748 | 1/20 | 0.31 |
| ▸ | ATR | Q13535 | 4/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.31 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8091877 | 0.82 | PIK3CA (0.39) | PIK3CAMAPK1PIK3CBMTORPIK3R1 | |
| SCHEMBL8090668 | 0.81 | PIK3CA (0.35) | PIK3CAMAPK1PIK3CBMTORPIK3R1 | |
| SCHEMBL8099656 | 0.77 | PIK3CD (0.39) | PIK3CAPIK3CBMTORKDM1AMAOA | |
| SCHEMBL8098293 | 0.75 | PIK3CA (0.42) | PIK3CAMTORATR | |
| SCHEMBL8091781 | 0.73 | CA12 (0.43) | PIK3CAMTORATRROCK2 | |
| SCHEMBL8097556 | 0.73 | PIK3CA (0.42) | PIK3CAMTORATR | |
| SCHEMBL8083011 | 0.72 | ATR (0.39) | PIK3CAMTORATR | |
| SCHEMBL8091635 | 0.71 | ATR (0.47) | PIK3CAMTORFLT4ATRROCK2 | |
| SCHEMBL8091693 | 0.71 | MTOR (0.40) | PIK3CAMAPK1MTORMAOAFLT4 | |
| SCHEMBL8097252 | 0.71 | CA12 (0.43) | PIK3CAMTORATRROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |