Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 4/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | KIF18A | Q8NI77 | 2/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | KDR | P35968 | 2/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCND1 | P24385 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK7 | P50613 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
| ▸ | CCNH | P51946 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8090843 | 0.87 | PIK3CA (0.45) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8094369 | 0.77 | PIK3CD (0.44) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8097098 | 0.77 | PIK3CA (0.46) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8091932 | 0.76 | FPR2 (0.40) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8097557 | 0.74 | PIK3CD (0.45) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL3930083 | 0.74 | MTOR (0.60) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8095926 | 0.74 | PIK3CA (0.43) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL8094419 | 0.73 | CXCR2 (0.38) | PIK3CAMTORPIK3CDPIK3CGFPR2 | |
| SCHEMBL11926125 | 0.69 | PIK3CA (0.42) | PIK3CAMTORPIK3CDPIK3CGFPR2 | |
| SCHEMBL3926444 | 0.68 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |