SCHEMBL8092326

SCHEMBL8092326

COc1ccc(CNC(C)Cc2ccccc2)cc1

nearest known ligand 0.76

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 4/20 0.74
MEN1 O00255 1/20 0.65
KMT2A Q03164 1/20 0.65
L3MBTL1 Q9Y468 2/20 0.63
SLC2A1 P11166 1/20 0.54
HTT P42858 1/20 0.54
BCHE P06276 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
LTA4H P09960 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL719011 1.00 SIGMAR1 (0.74) SIGMAR1MEN1KMT2AL3MBTL1SLC2A1
SCHEMBL2795948 1.00 SIGMAR1 (0.74) SIGMAR1MEN1KMT2AL3MBTL1SLC2A1
SCHEMBL593666 1.00 SIGMAR1 (0.74) SIGMAR1MEN1KMT2AL3MBTL1SLC2A1
Hydrochloric Acid SCHEMBL1134234 0.98 SIGMAR1 (0.72) SIGMAR1MEN1KMT2AL3MBTL1SLC2A1
Hydrochloric Acid SCHEMBL1134233 0.98 SIGMAR1 (0.72) SIGMAR1MEN1KMT2AL3MBTL1SLC2A1
SCHEMBL3341840 0.92 SIGMAR1 (0.62) SIGMAR1MEN1KMT2AL3MBTL1SLC2A1
SCHEMBL3341844 0.92 SIGMAR1 (0.62) SIGMAR1MEN1KMT2AL3MBTL1SLC2A1
SCHEMBL3346880 0.92 SIGMAR1 (0.62) SIGMAR1MEN1KMT2AL3MBTL1SLC2A1
SCHEMBL6539539 0.89 SIGMAR1 (0.59) SIGMAR1MEN1KMT2AL3MBTL1SLC2A1
SCHEMBL3630860 0.88 SIGMAR1 (0.57) SIGMAR1MEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
EP-0507863-A4 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF 1993-07-07 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed
EP-0507863-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1992-10-14 EP disclosed
WO-1991009594-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1991-07-11 WO disclosed