Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.65 |
| ▸ | DRD2 | P14416 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11531669 | 0.83 | DRD4 (0.69) | DRD4DRD2DRD3KDM4EALDH1A1 | |
| SCHEMBL13114791 | 0.82 | GAA (0.67) | DRD4DRD2MAPTDRD3KDM4E | |
| SCHEMBL12385909 | 0.81 | DRD4 (0.77) | DRD4DRD2MAPTDRD3KDM4E | |
| SCHEMBL25556655 | 0.81 | GAA (0.64) | DRD4DRD2MAPTKDM4EALDH1A1 | |
| SCHEMBL6905938 | 0.80 | LMNA (0.70) | DRD4DRD2MAPTDRD3KDM4E | |
| SCHEMBL588149 | 0.79 | DRD4 (1.00) | DRD4DRD2MAPTDRD3KDM4E | |
| SCHEMBL6031583 | 0.79 | KDM4E (0.62) | DRD4DRD2MAPTDRD3KDM4E | |
| SCHEMBL6032792 | 0.79 | DRD2 (0.57) | DRD4DRD2MAPTDRD3KDM4E | |
| SCHEMBL6806255 | 0.78 | ALDH1A1 (0.68) | DRD4MAPTKDM4EALDH1A1SIGMAR1 | |
| SCHEMBL6031812 | 0.78 | DRD4 (1.00) | DRD4DRD2DRD3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| EP-0507863-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | — | 1993-07-07 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |
| EP-0507863-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1992-10-14 | — | — | EP | disclosed |
| WO-1991009594-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1991-07-11 | — | — | WO | disclosed |