Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 8/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.55 |
| ▸ | CNR1 | P21554 | 9/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.40 |
| ▸ | CA1 | P00915 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8095632 | 0.99 | PTGS2 (0.56) | PTGS2PTGS1CNR1CA12CA1 | |
| SCHEMBL8094547 | 0.96 | PTGS2 (0.60) | PTGS2PTGS1CNR1CA12CA1 | |
| SCHEMBL8776822 | 0.91 | PTGS2 (0.56) | PTGS2PTGS1CNR1CNR2MEN1 | |
| SCHEMBL8087151 | 0.91 | PTGS2 (0.67) | PTGS2PTGS1CNR1 | |
| SCHEMBL8086370 | 0.90 | PTGS2 (0.68) | PTGS2PTGS1CNR1 | |
| SCHEMBL8094551 | 0.89 | CNR1 (0.49) | PTGS2PTGS1CNR1CA12CA1 | |
| SCHEMBL8094989 | 0.88 | PTGS2 (0.53) | PTGS2PTGS1CNR1CA12CA1 | |
| SCHEMBL8087099 | 0.87 | PTGS2 (0.48) | PTGS2PTGS1CNR1CA12CA1 | |
| SCHEMBL8093419 | 0.87 | PTGS2 (0.72) | PTGS2PTGS1CNR1CNR2 | |
| SCHEMBL8098696 | 0.86 | PTGS2 (0.47) | PTGS2PTGS1CNR1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | claimed |
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| EP-0808304-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1997-11-26 | — | — | EP | disclosed |
| WO-1996024584-A1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-15 | — | — | WO | disclosed |