Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.42 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8099660 | 0.92 | MAPT (0.49) | PTGS2MAPTPTGS1HIF1ACNR1 | |
| SCHEMBL8099266 | 0.84 | PTGS2 (0.53) | PTGS2PTGS1MAPK8MAPK9 | |
| SCHEMBL8101771 | 0.83 | PTGS2 (0.54) | PTGS2PTGS1CNR1 | |
| SCHEMBL8101829 | 0.82 | PTGS2 (0.52) | PTGS2PTGS1 | |
| SCHEMBL8093657 | 0.82 | PTGS2 (0.56) | PTGS2PTGS1MAPK8MAPK9MAPK10 | |
| SCHEMBL8099373 | 0.82 | PTGS2 (0.51) | PTGS2PTGS1MAPK8MAPK9MAPK10 | |
| SCHEMBL8419819 | 0.81 | MAPT (0.48) | MAPTHIF1A | |
| SCHEMBL8095004 | 0.81 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL8094067 | 0.79 | PTGS2 (0.49) | PTGS2PTGS1CNR1 | |
| SCHEMBL8095119 | 0.79 | HPGD (0.47) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808304-B1 | 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION | SEARLE & CO (US) | 2000-12-27 | — | — | EP | disclosed |
| US-5916905-A | ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS | G. D. SEARLE & CO. (US) | 1999-06-29 | — | — | US | disclosed |
| US-5686470-A | 2, 3-substituted pyridines for the treatment of inflammation | WEIER RICHARD M (US) | 1997-11-11 | — | — | US | disclosed |