Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL6654997 | 0.94 | CYP2C19 (0.44) | ALOX15TSHRPTPN1CYP2D6CYP2C19 | |
| Ethylene Glycol SCHEMBL2116930 | 0.93 | ALOX15 (0.52) | ALOX15TSHRHSD17B10ALDH1A1HPGD | |
| Ethylene Glycol SCHEMBL5604837 | 0.93 | ALOX15 (0.52) | ALOX15TSHRHSD17B10ALDH1A1HPGD | |
| Terephthalic Acid SCHEMBL17685563 | 0.93 | ALOX15 (0.52) | ALOX15TSHRTP53PTPN1HSD17B10 | |
| Terephthalic Acid SCHEMBL7867064 | 0.91 | ALOX15 (0.50) | ALOX15TSHRTP53PTPN1HSD17B10 | |
| Terephthalic Acid SCHEMBL20545564 | 0.91 | ALOX15 (0.50) | ALOX15TSHRTP53PTPN1HSD17B10 | |
| Ethylene Glycol SCHEMBL8066613 | 0.89 | ALOX15 (0.49) | ALOX15TSHRHSD17B10ALDH1A1HPGD | |
| Terephthalic Acid SCHEMBL17457900 | 0.86 | PTPN1 (0.49) | ALOX15TSHRPTPN1HSD17B10HPGD | |
| SCHEMBL65889 | 0.85 | ALOX15 (0.59) | ALOX15TSHRHSD17B10ALDH1A1HPGD | |
| Benzene SCHEMBL10638262 | 0.85 | ALOX15 (0.59) | ALOX15TSHRHSD17B10ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6131512-A | Printing master comprising strain gauges | AGFA-GEVAERT, N.V. (BE) | 2000-10-17 | — | — | US | disclosed |