SCHEMBL8092954

SCHEMBL8092954

FC(F)(F)c1cccc(CCCNCCCc2ccccc2)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 9/20 0.64
CYP2D6 P10635 2/20 0.64
TP53 P04637 1/20 0.64
CYP1A2 P05177 1/20 0.64
CYP3A4 P08684 1/20 0.64
TSHR P16473 1/20 0.64
CYP2C19 P33261 1/20 0.64
TAAR1 Q96RJ0 1/20 0.56
HDAC1 Q13547 1/20 0.55
HDAC8 Q9BY41 1/20 0.55
ADRA2C P18825 2/20 0.54
SLC6A2 P23975 2/20 0.54
HTR2C P28335 2/20 0.54
SLC6A4 P31645 2/20 0.54
OPRM1 P35372 2/20 0.54
DRD3 P35462 2/20 0.54
CASR P41180 2/20 0.54
MLNR O43193 1/20 0.54
ABCB11 O95342 1/20 0.54
ADRB1 P08588 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9989291 0.95 TAAR1 (0.61) SIGMAR1CYP2D6TP53CYP1A2CYP3A4
SCHEMBL11383498 0.88 TAAR1 (0.65) SIGMAR1CYP2D6TP53CYP1A2CYP3A4
SCHEMBL12040551 0.86 TAAR1 (0.62) SIGMAR1CYP2D6TP53CYP1A2CYP3A4
SCHEMBL3508827 0.86 SIGMAR1 (0.63) SIGMAR1CYP2D6TP53CYP1A2CYP3A4
SCHEMBL16212524 0.82 ADRA2C (0.60) SIGMAR1CYP2D6TP53CYP1A2CYP3A4
SCHEMBL6265706 0.82 SIGMAR1 (0.58) SIGMAR1CYP2D6TP53CYP1A2CYP3A4
Hydrochloric Acid SCHEMBL1504932 0.81 SIGMAR1 (0.60) SIGMAR1CYP2D6TP53CYP1A2CYP3A4
SCHEMBL5535930 0.81 TAAR1 (0.53) SIGMAR1CYP2D6TP53CYP1A2CYP3A4
SCHEMBL22579188 0.81 KDM4E (0.63) SIGMAR1CYP2D6TP53CYP1A2CYP3A4
SCHEMBL8084196 0.80 SIGMAR1 (0.59) SIGMAR1CYP2D6TP53CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6057371-A TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION VIRGINIA COMMONWEALTH UNIVERSITY (US) 2000-05-02 US disclosed
EP-0591426-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1994-04-13 EP disclosed
EP-0507863-A4 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF 1993-07-07 EP disclosed
WO-1993000313-A2 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1993-01-07 WO disclosed
EP-0507863-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1992-10-14 EP disclosed
WO-1991009594-A1 SIGMA RECEPTOR LIGANDS AND THE USE THEREOF VIRGINIA COMMONWEALTH UNIVERSITY (US) 1991-07-11 WO disclosed