Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | CASR | P41180 | 2/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8092954 | 0.95 | SIGMAR1 (0.64) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 | |
| SCHEMBL6265706 | 0.86 | SIGMAR1 (0.58) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 | |
| SCHEMBL5535930 | 0.85 | TAAR1 (0.53) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 | |
| SCHEMBL16212524 | 0.84 | ADRA2C (0.60) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 | |
| SCHEMBL12521121 | 0.83 | SCN8A (0.54) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 | |
| Hydrochloric Acid SCHEMBL1504932 | 0.83 | SIGMAR1 (0.60) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 | |
| SCHEMBL5535926 | 0.82 | TAAR1 (0.53) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 | |
| SCHEMBL11383498 | 0.81 | TAAR1 (0.65) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 | |
| SCHEMBL10562876 | 0.81 | TAAR1 (0.56) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 | |
| SCHEMBL5540234 | 0.81 | HDAC1 (0.54) | TAAR1SIGMAR1CYP2D6TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575395-B2 | Method for the preparation of cinacalcet and intermediates and impurities thereof | Amneal Pharmaceuticals, LLC (US) | 2013-11-05 | — | — | US | disclosed |
| US-20110319663-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | Amneal Pharmaceuticals, LLC (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319663-A1 | Method For The Preparation Of Cinacalcet And Intermediates And Impurities Thereof | CMA1, SI, ALDH1A1 | TAAR1 1331/4885SIGMAR1 383/4885CYP2D6 748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.