Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | KDM6B | O15054 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8084522 | 0.95 | HDAC6 (0.51) | L3MBTL1KMT2AMEN1SIGMAR1GAA | |
| SCHEMBL6513356 | 0.88 | GAA (0.54) | L3MBTL1KMT2AMEN1SIGMAR1GAA | |
| SCHEMBL10407866 | 0.82 | POLB (0.54) | L3MBTL1SIGMAR1GAAHDAC6 | |
| SCHEMBL3248990 | 0.81 | POLB (0.53) | L3MBTL1 | |
| SCHEMBL10408718 | 0.81 | POLB (0.53) | L3MBTL1 | |
| SCHEMBL10407954 | 0.81 | POLB (0.53) | L3MBTL1 | |
| SCHEMBL3966040 | 0.80 | POLB (0.60) | L3MBTL1GAAKDM6BKDM4CKDM4E | |
| SCHEMBL30806170 | 0.80 | MAPT (0.54) | KMT2AMEN1SIGMAR1GAAHDAC6 | |
| SCHEMBL18289061 | 0.78 | ALDH1A1 (0.43) | L3MBTL1GAA | |
| SCHEMBL19495506 | 0.78 | HSD17B10 (0.53) | L3MBTL1GAAKDM4EGRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |