Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | KDM6B | O15054 | 1/20 | 0.48 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8093196 | 0.95 | L3MBTL1 (0.53) | HDAC6GAAKMT2ASIGMAR1MEN1 | |
| SCHEMBL6513356 | 0.89 | GAA (0.54) | GAAKMT2ASIGMAR1MEN1GRM2 | |
| SCHEMBL3966040 | 0.82 | POLB (0.60) | HDAC6GAACYP2C9CYP2C19POLB | |
| SCHEMBL30806170 | 0.81 | MAPT (0.54) | HDAC6GAAKMT2ASIGMAR1MEN1 | |
| SCHEMBL10407866 | 0.80 | POLB (0.54) | HDAC6GAASIGMAR1CYP2C9CYP2C19 | |
| SCHEMBL18289061 | 0.80 | ALDH1A1 (0.43) | GAAHPGDPOLBL3MBTL1 | |
| SCHEMBL19495506 | 0.79 | HSD17B10 (0.53) | GAAGRM2HPGDPOLBHDAC8 | |
| Hydrochloric Acid SCHEMBL2343034 | 0.79 | MAPT (0.52) | HDAC6GAAKMT2ASIGMAR1MEN1 | |
| SCHEMBL11598417 | 0.79 | MAPT (0.64) | HDAC6GAAKMT2ASIGMAR1MEN1 | |
| SCHEMBL10407954 | 0.79 | POLB (0.53) | POLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6057371-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, GASTROINTESTINAL DISORDERS, DRUG ABUSE, ANGINA, MIGRAINE, HYPERTENSION AND DEPRESSION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2000-05-02 | — | — | US | disclosed |
| EP-0591426-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1994-04-13 | — | — | EP | disclosed |
| WO-1993000313-A2 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 1993-01-07 | — | — | WO | disclosed |