Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032381 | 0.89 | KDM4E (0.50) | ALDH1A1KDM4ECYP19A1NR3C1THRB | |
| SCHEMBL14957482 | 0.81 | TNKS2 (0.46) | ALDH1A1KDM4EHPGDKMT2AMAPT | |
| SCHEMBL8093303 | 0.81 | ANPEP (0.41) | ALDH1A1THRBHPGDMEN1KMT2A | |
| Methoxymethane SCHEMBL27610365 | 0.78 | KDM4E (0.42) | ALDH1A1KDM4ECYP19A1NR3C1HPGD | |
| SCHEMBL128290 | 0.78 | AR (0.49) | ALDH1A1THRBHSD17B10MEN1KMT2A | |
| SCHEMBL27279995 | 0.78 | KDM4E (0.45) | ALDH1A1KDM4ECYP19A1THRBHSD17B10 | |
| SCHEMBL127705 | 0.77 | MAPT (0.52) | CYP19A1HPGDMAPTLMNA | |
| SCHEMBL27183319 | 0.77 | CYP19A1 (0.48) | ALDH1A1CYP19A1HPGDHSD17B10MEN1 | |
| SCHEMBL5084443 | 0.77 | MEN1 (0.49) | CYP19A1NR3C1MEN1KMT2AL3MBTL1 | |
| SCHEMBL27520016 | 0.76 | NR3C1 (0.36) | ALDH1A1KDM4ENR3C1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6046231-A | ADMINISTERING A SUFFICIENT AMOUNT OF A CANCER CHEMOPREVENTATIVE COMPOSITION COMPRISING 4'-BROMOFLAVONE TO A MAMMAL IN NEED TO PREVENT, DELAY OR REVERSE A CANCER SENSITIVE TO 4'-BROMOFLAVONE | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2000-04-04 | — | — | US | disclosed |