SCHEMBL8093312

SCHEMBL8093312

COc1nc(-c2cccc(Cl)c2)c(-c2ccc(S(N)(=O)=O)cc2)cc1C#N

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.47
CA2 P00918 1/20 0.47
CNR1 P21554 11/20 0.47
CNR2 P34972 7/20 0.47
KDM4E B2RXH2 2/20 0.42
PTGS1 P23219 1/20 0.42
PTGS2 P35354 1/20 0.42
POLB P06746 1/20 0.41
SQOR Q9Y6N5 1/20 0.41
SCN9A Q15858 1/20 0.41
ADORA2A P29274 1/20 0.40
ADORA2B P29275 1/20 0.40
ADORA1 P30542 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
AKT1 P31749 1/20 0.40
AKT2 P31751 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8099937 0.91 CNR1 (0.48) CNR1CNR2PTGS1PTGS2SQOR
SCHEMBL8776752 0.89 CNR1 (0.48) CNR1CNR2SQORSCN9AAKT1
SCHEMBL8087245 0.88 KDM4E (0.51) CA1CA2CNR1KDM4EPTGS1
SCHEMBL8086726 0.88 CA4 (0.46) CNR1CNR2KDM4EPTGS1PTGS2
SCHEMBL8092465 0.88 PTGS2 (0.46) CA1CA2CNR1CNR2KDM4E
SCHEMBL8093990 0.86 CNR1 (0.64) CNR1CNR2
SCHEMBL8094767 0.84 CNR1 (0.52) CA1CA2CNR1CNR2KDM4E
SCHEMBL8093896 0.84 PTGS2 (0.45) CNR1CNR2KDM4EPTGS1PTGS2
SCHEMBL8093867 0.84 PTGS2 (0.55) CA1CA2CNR1CNR2KDM4E
SCHEMBL8096123 0.84 PTGS2 (0.47) CA1CA2CNR1CNR2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0808304-B1 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION SEARLE & CO (US) 2000-12-27 EP claimed
EP-0808304-A1 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1997-11-26 EP claimed
WO-1996024584-A1 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-08-15 WO claimed
EP-0808304-B1 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION SEARLE & CO (US) 2000-12-27 EP disclosed
EP-0808304-A1 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1997-11-26 EP disclosed
WO-1996024584-A1 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-08-15 WO disclosed