SCHEMBL8093471

SCHEMBL8093471

O=C(O)c1ccc(-n2cc(-c3cn[nH]c3)cn2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPKAPK2 P49137 1/20 0.48
MAP4K4 O95819 1/20 0.48
HPGDS O60760 1/20 0.48
ALKBH2 Q6NS38 1/20 0.48
ROCK2 O75116 3/20 0.43
NPC1 O15118 2/20 0.42
RAB9A P51151 2/20 0.42
HSD11B1 P28845 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
AKT1 P31749 1/20 0.40
AKT2 P31751 1/20 0.40
MELK Q14680 2/20 0.39
CHEK1 O14757 1/20 0.39
MAOA P21397 1/20 0.39
MAOB P27338 1/20 0.39
DNM1L O00429 1/20 0.38
GRM4 Q14833 1/20 0.37
HSP90AA1 P07900 1/20 0.37
NFKB1 P19838 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL182369 0.81 HPGDS (0.63) MAPKAPK2MAP4K4HPGDSALKBH2NPC1
SCHEMBL6134377 0.80 ALKBH2 (0.66) MAPKAPK2MAP4K4HPGDSALKBH2NPC1
SCHEMBL17442798 0.78 ROCK2 (0.59) ROCK2AKT1AKT2
SCHEMBL182439 0.78 MELK (0.59) MAPKAPK2MAP4K4HPGDSALKBH2NPC1
SCHEMBL182124 0.77 MAP4K4 (0.57) MAPKAPK2MAP4K4HPGDSALKBH2NPC1
SCHEMBL180639 0.77 BCL2L1 (0.59) MAPKAPK2MAP4K4HPGDSALKBH2NPC1
SCHEMBL182190 0.77 MAP4K4 (0.77) MAPKAPK2MAP4K4HPGDSALKBH2NPC1
SCHEMBL182203 0.77 MAP4K4 (0.57) MAPKAPK2MAP4K4HPGDSALKBH2NPC1
SCHEMBL182033 0.77 MAP4K4 (0.77) MAPKAPK2MAP4K4HPGDSALKBH2NPC1
SCHEMBL182164 0.77 MAPKAPK2 (0.79) MAPKAPK2MAP4K4HPGDSALKBH2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6121305-A 5,5'-DIHYDROXY-4,4'-BIPYRAZOLE COMPOUNDS OF GIVEN FORMULA; FREE RADICAL SCAVENGER; USE TO TREAT CEREBRAL ISCHEMIA, HEART DISEASE, CARCINOMA, AGING, INFLAMMATION OR DIGESTIVE SYSTEM DISEASE, OR IN DETECTION OF AN ACTIVE OXYGEN OR FREE RADICALS DAIICHI RADIOISOTOPE LABORATORIES, LTD. (JP) 2000-09-19 US disclosed