Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | MPI | P34949 | 1/20 | 0.34 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.34 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4321443 | 1.00 | — | — | |
| SCHEMBL8101327 | 0.94 | BRD4 (0.39) | BRD4KMT2AMEN1GRIA2ADRA2A | |
| SCHEMBL10133984 | 0.87 | BRD4 (0.38) | BRD4KMT2AMEN1GRIA2ADRA2A | |
| SCHEMBL9369777 | 0.83 | BRD4 (0.50) | BRD4KMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL4316094 | 0.83 | ADRA2A (0.51) | BRD4KMT2AMEN1ADRA2AADRA2B | |
| SCHEMBL8107425 | 0.83 | ADRA2A (0.51) | BRD4KMT2AMEN1ADRA2AADRA2B | |
| SCHEMBL8301100 | 0.81 | ALDH1A1 (0.50) | BRD4KMT2AMEN1ALDH1A1NPSR1 | |
| SCHEMBL8103457 | 0.80 | ALDH1A1 (0.44) | KMT2AMEN1ADRA2AADRA2BADRA2C | |
| SCHEMBL8101881 | 0.79 | ALDH1A1 (0.43) | KMT2AMEN1ADRA2AADRA2BADRA2C | |
| SCHEMBL19481567 | 0.79 | ADRA2B (0.44) | KMT2AMEN1ADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127369-A | 5,10-dihydrodipyrido[2,3-b:2,3-e]pyrazin and 5,10-dihydrodipyrido[2,3-b:3,2-e]pyrazin compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |