Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.44 |
| ▸ | MTOR | P42345 | 3/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1755648 | 0.90 | PIK3CA (0.55) | POLBALDH1A1PIK3CAMTORPIK3CD | |
| SCHEMBL8205071 | 0.90 | PIK3CA (0.54) | POLBALDH1A1PIK3CAMTORPIK3CD | |
| SCHEMBL8086866 | 0.88 | MAPT (0.44) | ALDH1A1PIK3CAMTORPIK3CDMEN1 | |
| SCHEMBL8099679 | 0.88 | PIK3CD (0.52) | ALDH1A1PIK3CAMTORPIK3CDKMT2A | |
| SCHEMBL11925797 | 0.83 | PIK3CA (0.49) | POLBALDH1A1PIK3CAMTORPIK3CD | |
| SCHEMBL11926032 | 0.83 | ALDH1A1 (0.46) | POLBALDH1A1PIK3CAMTORPIK3CD | |
| SCHEMBL8215196 | 0.82 | CA12 (0.49) | POLBALDH1A1PIK3CAMTORPIK3CD | |
| SCHEMBL8205971 | 0.82 | NPC1 (0.44) | POLBALDH1A1PIK3CAMTORPIK3CD | |
| SCHEMBL8093349 | 0.81 | PIK3CD (0.48) | POLBALDH1A1PIK3CAMTORPIK3CD | |
| SCHEMBL8101524 | 0.81 | MEN1 (0.54) | ALDH1A1PIK3CAMTORPIK3CDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007750-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |