Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.65 |
| ▸ | DRD3 | P35462 | 8/20 | 0.65 |
| ▸ | DRD4 | P21917 | 5/20 | 0.65 |
| ▸ | HTR1A | P08908 | 4/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | CASP1 | P29466 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | FYN | P06241 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8694386 | 0.89 | DRD3 (0.58) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL8094252 | 0.81 | DRD3 (0.54) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL8094256 | 0.81 | DRD3 (0.54) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL17446285 | 0.80 | DRD2 (0.72) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL7405845 | 0.79 | DRD3 (0.54) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL7408204 | 0.79 | DRD3 (0.54) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL7405840 | 0.79 | DRD3 (0.54) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL7408200 | 0.79 | DRD3 (0.54) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL7411429 | 0.79 | DRD2 (0.70) | DRD2DRD3DRD4HTR1AMEN1 | |
| SCHEMBL623950 | 0.79 | DRD2 (1.00) | DRD2DRD3DRD4HTR1AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0435988-A1 | 2-AMINO-7-CARBAMOYL-1,2,3,4-TETRAHYDRONAPHTHALENES, PROCESS FOR PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM KG (DE) | 1991-07-10 | — | — | EP | disclosed |
| WO-1991001297-A1 | 2-AMINO-7-CARBAMOYL-1,2,3,4-TETRAHYDRONAPHTHALENES, PROCESS FOR PREPARING THEM AND THEIR USE AS DRUGS | BOEHRINGER INGELHEIM KG (DE) | 1991-02-07 | — | — | WO | disclosed |