Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA2 | P29317 | 1/20 | 0.53 |
| ▸ | FLT4 | P35916 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL500692 | 0.91 | LMNA (0.56) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL10445662 | 0.90 | RORC (0.52) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL9147090 | 0.89 | EPHA2 (0.53) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL2087613 | 0.86 | LMNA (0.53) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL10330764 | 0.86 | LMNA (0.55) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL6216178 | 0.86 | LMNA (0.50) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL10512040 | 0.85 | EPHA2 (0.52) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL9046561 | 0.84 | EPHA2 (0.39) | EPHA2FLT4GSK3BRARBTBXAS1 | |
| SCHEMBL10516924 | 0.83 | LMNA (0.60) | LMNAKMT2AMEN1KDM4EALDH1A1 | |
| SCHEMBL10412629 | 0.83 | LMNA (0.50) | EPHA2FLT4GSK3BRARBTBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6018054-A | INTERMEDIATE COMPOUNDS FOR PREPARING NOVEL QUINOLONE AND NAPHTHYRIDONE DERIVATIVES WHICH ARE SUBSTITUTED IN THE 7-POSITION BY A PARTIALLY HYDROGENATED ISOINDOLINYL RING, USE AS ANTIBACTERIAL AGENTS AND AS FEED ADDITIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-01-25 | — | — | US | disclosed |
| US-5739339-A | BACTERICIDES, ANTIPROTOZOA AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-04-14 | — | — | US | disclosed |
| US-5556979-A | ANIMAL FEEDS | BAYER AKTIENGESELLSCHAFT (DE) | 1996-09-17 | — | — | US | disclosed |
| EP-0588166-B1 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1996-06-05 | — | — | EP | disclosed |
| EP-0588166-A2 | Antibacterial 7-isoindolinyl-quinolone and naphthyridone derivatives | BAYER AG (DE) | 1994-03-23 | — | — | EP | disclosed |
| EP-0338372-A2 | Solubilized pro-drugs | AMERICAN CYANAMID COMPANY (US) | 1989-10-25 | — | — | EP | disclosed |
| EP-0302371-A2 | 7-(2-Methyl-4-aminopyrrolidinyl)naphthyridine and quinoline compounds | ABBOTT LABORATORIES (US) | 1989-02-08 | — | — | EP | disclosed |