Sugi Predict

Sugi Predict / Compounds / SCHEMBL500692

SCHEMBL500692

SCHEMBL500692

O=C(O)c1cn(-c2ccc(F)cc2F)c2cc(F)c(F)cc2c1=O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 5/20 0.56
▸ KMT2A Q03164 2/20 0.56
▸ MEN1 O00255 1/20 0.56
▸ ALDH1A1 P00352 7/20 0.55
▸ KDM4E B2RXH2 7/20 0.55
▸ HSD17B10 Q99714 5/20 0.55
▸ HPGD P15428 4/20 0.55
▸ EPHA2 P29317 1/20 0.54
▸ FLT4 P35916 1/20 0.54
▸ GSK3B P49841 1/20 0.54
▸ RARB P10826 1/20 0.54
▸ TBXAS1 P24557 1/20 0.54
▸ SLC6A3 Q01959 1/20 0.54
▸ POLB P06746 2/20 0.49
▸ HTT P42858 2/20 0.49
▸ XBP1 P17861 1/20 0.49
▸ NFKB1 P19838 1/20 0.49
▸ NFKB2 Q00653 1/20 0.49
▸ RELA Q04206 1/20 0.49
▸ HSP90AA1 P07900 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8094560 0.91 EPHA2 (0.53) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL9147090 0.91 EPHA2 (0.53) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL10330764 0.90 LMNA (0.55) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL6216178 0.90 LMNA (0.50) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL2087613 0.90 LMNA (0.53) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL9046825 0.89 LMNA (0.51) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL30298036 0.88 CAPN1 (0.54) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL10860012 0.88 CAPN1 (0.54) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL14860174 0.87 TOP1 (0.55) LMNAKMT2AMEN1ALDH1A1KDM4E
SCHEMBL10412629 0.87 LMNA (0.50) LMNAKMT2AMEN1ALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1666477-B1 7-(4-SUBSTITUTED 3- CYCLOPROPYLAMINOMETHYL-1- PYRROLIDINYL) Q UINOLONECARBOXYLIC ACID DERIVATIVE KYORIN SEIYAKU KK (JP) 2013-07-03 — — EP disclosed
US-8106072-B2 7- (4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl) quinolonecarboxylic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2012-01-31 — — US disclosed
US-20090176824-A1 7- (4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl) quinolonecarboxylic acid derivative technical field ASAHINA YOSHIKAZU 2009-07-09 — — US disclosed
US-7514451-B2 7-(4-Substituted-3-cyclopropylaminomethyl-1 pyrrolidinyl) quinolonecarboxylic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2009-04-07 — — US disclosed
EP-1572657-B1 PROCESSES FOR PREPARING QUINOLONECARBOXYLATE DERIVATIVES YUHAN CORP (KR) 2007-07-11 — — EP disclosed
US-20060281779-A1 7-(4-Substituted-3-cyclopropylaminomethyl-1 pyrrolidinyl) quinolonecarboxylic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2006-12-14 — — US disclosed
US-7098219-B2 Quinolone derivatives WOCKHART LIMITED (IN) 2006-08-29 — — US disclosed
EP-1666477-A1 7-(4-SUBSTITUTED 3- CYCLOPROPYLAMINOMETHYL-1- PYRROLIDINYL) Q UINOLONECARBOXYLIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2006-06-07 — — EP disclosed
EP-1572657-A4 PROCESSES FOR PREPARING QUINOLONECARBOXYLATE DERIVATIVES YUHAN CORP (KR) 2006-03-01 — — EP disclosed
EP-1572657-A1 PROCESSES FOR PREPARING QUINOLONECARBOXYLATE DERIVATIVES Yuhan Corporation (KR) 2005-09-14 — — EP disclosed
EP-0550016-A1 Novel quinolone carboxylic acid derivatives and processes for preparing same KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 1993-07-07 — — EP disclosed
US-5217972-A QUINOLONECARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIVIRAL AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1993-06-08 — — US disclosed
EP-0520240-A1 7-Isoindolinyl-quinolone and naphthyridonecarboxylic acid derivatives BAYER AG (DE) 1992-12-30 — — EP disclosed
US-5164402-A Bactericides PFIZER INC (US) 1992-11-17 — — US disclosed
US-5137892-A Bactericides ABBOTT LABORATORIES (US) 1992-08-11 — — US disclosed
WO-1992010191-A1 QUINOLINE, NAPHTHYRIDINE AND PYRIDOBENZOXAZINE DERIVATIVES ABBOTT LABORATORIES (US) 1992-06-25 — — WO disclosed
US-5091383-A SUBSTITUTED BRIDGED DIAZABICYCLOALKYL QUINOLONE CARBOXYLIC ACIDS PFIZER INC. (US) 1992-02-25 — — US disclosed
US-5045549-A Bactericides CHEMIE LINZ GESELLSCHAFT M.B.H. (AT) 1991-09-03 — — US disclosed
EP-0422485-A2 Quinolone carboxylic acid derivatives, process for their preparation and their use BAYER AG (DE) 1991-04-17 — — EP disclosed
US-4927926-A BACTERICIDES LABORATORIOS DEL DR. ESTEVE S.A. (ES) 1990-05-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090176824-A1 7- (4-substituted-3-cyclopropylaminomethyl-1-pyrrolidinyl) quinolonecarboxylic acid derivative technical field CLPP, PRSS1, FOSB LMNA 4044/4885KMT2A 4292/4885MEN1 4411/4885
US-20060281779-A1 7-(4-Substituted-3-cyclopropylaminomethyl-1 pyrrolidinyl) quinolonecarboxylic acid derivative RPS27L, RPS7, RPSA LMNA 3148/4885KMT2A 4168/4885MEN1 4367/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.