Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 9/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 9/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8081261 | 0.91 | AGTR1 (0.48) | AGTR1AGTR2PPARG | |
| SCHEMBL9122396 | 0.85 | AGTR1 (0.66) | AGTR1AGTR2PPARG | |
| SCHEMBL8972401 | 0.84 | PPARG (0.70) | AGTR1AGTR2PPARG | |
| SCHEMBL9125406 | 0.81 | AGTR1 (0.74) | AGTR1AGTR2PPARG | |
| SCHEMBL9128114 | 0.81 | AGTR1 (0.53) | AGTR1AGTR2 | |
| SCHEMBL9847764 | 0.80 | PPARG (0.55) | AGTR1AGTR2PPARG | |
| SCHEMBL9128138 | 0.80 | PPARG (0.53) | AGTR1AGTR2PPARG | |
| SCHEMBL22465117 | 0.79 | NLRP3 (0.47) | NLRP3 | |
| SCHEMBL29668407 | 0.79 | NLRP3 (0.47) | NLRP3 | |
| SCHEMBL9124957 | 0.79 | CYP1A2 (0.44) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |
| EP-0505893-A1 | Imidazopyridines | MERCK PATENT GmbH (DE) | 1992-09-30 | — | — | EP | disclosed |