Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.36 |
| ▸ | ITGAL | P20701 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262107 | 0.77 | ITGB1 (0.36) | ALDH1A1SMN1; SMN2MAPK1ITGB1ITGA5 | |
| SCHEMBL11262117 | 0.77 | ITGB1 (0.36) | ALDH1A1SMN1; SMN2MAPK1ITGB1ITGA5 | |
| SCHEMBL8102643 | 0.76 | TSHR (0.37) | ALDH1A1SMN1; SMN2ITGB1ITGA5ITGB3 | |
| SCHEMBL10948404 | 0.75 | TSHR (0.42) | ALDH1A1ITGB1ITGA5ITGB3ITGB2 | |
| SCHEMBL10948414 | 0.75 | TSHR (0.42) | ALDH1A1ITGB1ITGA5ITGB3ITGB2 | |
| SCHEMBL9836292 | 0.72 | ITGB1 (0.59) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL10968083 | 0.72 | ITGB1 (0.59) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL9836299 | 0.72 | ITGB1 (0.59) | ITGB1ITGA5ITGB3ITGB2ITGAV | |
| SCHEMBL10814097 | 0.69 | TSHR (0.46) | ALDH1A1MAPK1ITGB1ITGA5ITGB3 | |
| SCHEMBL11169353 | 0.68 | ITGB1 (0.36) | ITGB1ITGA5ITGB3ITGB2ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | disclosed |
| EP-0053815-B1 | 2-OXOAZETIDINE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1985-05-08 | — | — | EP | disclosed |