Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 6/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108497 | 0.91 | PLA2G7 (0.38) | PLA2G7NAMPTALDH1A1TSHRKDM4E | |
| SCHEMBL8440371 | 0.90 | PLA2G7 (0.40) | PLA2G7NAMPTALDH1A1TSHRKDM4E | |
| SCHEMBL8104179 | 0.88 | PLA2G7 (0.42) | PLA2G7NAMPTALDH1A1TSHRKDM4E | |
| SCHEMBL8552851 | 0.85 | PLA2G7 (0.39) | PLA2G7NAMPTALDH1A1TSHRKDM4E | |
| SCHEMBL8094721 | 0.85 | PLA2G7 (0.43) | PLA2G7NAMPTALDH1A1TSHRKDM4E | |
| SCHEMBL8104153 | 0.80 | EPHX2 (0.35) | PLA2G7NAMPTALDH1A1TSHRKDM4E | |
| SCHEMBL8443487 | 0.79 | KMT2A (0.48) | PLA2G7ALDH1A1TSHRKDM4ETDP1 | |
| SCHEMBL8442258 | 0.79 | TDP1 (0.34) | PLA2G7NAMPTALDH1A1TSHRKDM4E | |
| SCHEMBL8094761 | 0.79 | TSHR (0.42) | PLA2G7NAMPTALDH1A1TSHRKDM4E | |
| SCHEMBL8440358 | 0.78 | PLA2G7 (0.44) | PLA2G7ALDH1A1KDM4ETDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | disclosed |