Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 6/20 | 0.39 |
| ▸ | ASAH1 | Q13510 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8592738 | 0.90 | PLA2G7 (0.41) | PLA2G7ASAH1KDM4EALDH1A1TDP1 | |
| SCHEMBL8440371 | 0.85 | PLA2G7 (0.40) | PLA2G7ASAH1KDM4EALDH1A1TDP1 | |
| SCHEMBL8094854 | 0.85 | PLA2G7 (0.39) | PLA2G7ASAH1KDM4EALDH1A1TDP1 | |
| SCHEMBL8593281 | 0.84 | PLA2G7 (0.34) | PLA2G7ASAH1KDM4EALDH1A1TDP1 | |
| SCHEMBL8108497 | 0.83 | PLA2G7 (0.38) | PLA2G7ASAH1KDM4EALDH1A1TDP1 | |
| SCHEMBL8594638 | 0.80 | PLA2G7 (0.41) | PLA2G7ASAH1KDM4EALDH1A1TDP1 | |
| SCHEMBL8443487 | 0.79 | KMT2A (0.48) | PLA2G7ASAH1KDM4EALDH1A1TDP1 | |
| SCHEMBL8440358 | 0.77 | PLA2G7 (0.44) | PLA2G7KDM4EALDH1A1TDP1POLB | |
| SCHEMBL8438730 | 0.77 | PLA2G7 (0.45) | PLA2G7KDM4EALDH1A1TDP1TSHR | |
| SCHEMBL8094721 | 0.77 | PLA2G7 (0.43) | PLA2G7ASAH1KDM4EALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | claimed |
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |