Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8702070 | 0.77 | JAK2 (0.37) | HSD17B10JAK2JAK1 | |
| SCHEMBL20183521 | 0.74 | HSD17B10 (0.53) | HSD17B10TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL9479014 | 0.72 | ALDH1A1 (0.40) | HSD17B10TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL8953484 | 0.69 | MYC (0.38) | HSD17B10TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL7435402 | 0.69 | ESR2 (0.56) | HSD17B10TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL6696407 | 0.69 | HSD17B10 (0.50) | HSD17B10TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL9034499 | 0.69 | BDKRB1 (0.46) | HSD17B10TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL12497420 | 0.68 | APP (0.54) | HSD17B10TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL10061705 | 0.68 | ESR2 (0.54) | HSD17B10TSHRKDM4EHPGDALDH1A1 | |
| SCHEMBL3475619 | 0.67 | KDM4E (1.00) | HSD17B10TSHRKDM4EHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6037349-A | HAVING ANTAGONISTIC PROPERTIES TOWARDS ANGIOTENSIN II CAN BE USED FOR THE TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GMBH (DE) | 2000-03-14 | — | — | US | disclosed |
| US-5798364-A | ANGIOTENSIN II ANTAGONIST, USEFUL FOR TREATMENT OF HYPERTENSION, ALDOSTERONISM AND CARDIAC INSUFFICIENCY | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-08-25 | — | — | US | disclosed |