Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | CDK8 | P49336 | 1/20 | 0.57 |
| ▸ | CLK2 | P49760 | 1/20 | 0.57 |
| ▸ | GSK3A | P49840 | 1/20 | 0.57 |
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | CDK9 | P50750 | 1/20 | 0.57 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.57 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.57 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28873028 | 0.86 | KDM4E (0.75) | KDM4EHSD17B10HPGDTSHRPRKACA | |
| SCHEMBL27545525 | 0.86 | KDM4E (0.75) | KDM4EHSD17B10HPGDTSHRPRKACA | |
| SCHEMBL10330188 | 0.86 | KDM4E (0.75) | KDM4EHSD17B10HPGDTSHRPRKACA | |
| SCHEMBL29456651 | 0.84 | KDM4E (0.73) | KDM4EHSD17B10HPGDTSHRPRKACA | |
| SCHEMBL31519277 | 0.82 | TSHR (0.69) | KDM4EHSD17B10HPGDTSHRCYP19A1 | |
| SCHEMBL11468954 | 0.81 | HSD17B10 (0.68) | KDM4EHSD17B10HPGDTSHRPRKACA | |
| SCHEMBL12497079 | 0.80 | KDM4E (0.66) | KDM4EHSD17B10HPGDTSHRPRKACA | |
| SCHEMBL30607653 | 0.80 | TSHR (0.66) | KDM4EHSD17B10HPGDTSHRPRKACA | |
| SCHEMBL4571036 | 0.79 | HSD17B10 (0.71) | KDM4EHSD17B10HPGDTSHRMEN1 | |
| SCHEMBL30464743 | 0.79 | HSD17B10 (0.71) | KDM4EHSD17B10HPGDTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110313158-A1 | Two Component Recyclable Heterogeneous Catalyst, Process for Preparation Thereof and its Use for Preparation of Amines | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2011-12-22 | — | — | US | claimed |
| WO-2010097815-A2 | A TWO COMPONENT RECYCLABLE HETEROGENEOUS CATALYST, PROCESS FOR PREPARATION THEREOF AND ITS USE FOR PREPARATION OF AMINES | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-09-02 | — | — | WO | claimed |
| US-20240190837-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | SYCHRONICITY PHARMA INC (US) | 2024-06-13 | — | — | US | disclosed |
| US-20220411399-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | SYCHRONICITY PHARMA INC (US) | 2022-12-29 | — | — | US | disclosed |
| CN-110003172-B | Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators | 同步制药公司 | 2022-04-01 | — | — | CN | disclosed |
| EP-3939971-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | Synchronicity Pharma, Inc. (US) | 2022-01-19 | — | — | EP | disclosed |
| EP-3326715-B1 | OXALIC ACID MONOAMIDE LIGAND, AND USES THEREOF IN COUPLING REACTION OF COPPER-CATALYZED ARYL HALOGEN SUBSTITUTE | CE PHARM CO LTD (CN) | 2021-09-15 | — | — | EP | disclosed |
| US-20210171495-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | Synchronicity Pharma, Inc. | 2021-06-10 | — | — | US | disclosed |
| EP-3129366-B1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | SYNCHRONICITY PHARMA INC (US) | 2021-06-09 | — | — | EP | disclosed |
| US-10759777-B2 | Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators | Synchronicity Pharma, Inc. (US) | 2020-09-01 | — | — | US | disclosed |
| US-20190241540-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | Synchronicity Pharma, Inc. | 2019-08-08 | — | — | US | disclosed |
| US-20090149659-A1 | 1-ALKYL-3-AMINOINDAZOLES | ALCON, INC. (CH) | 2009-06-11 | — | — | US | disclosed |
| CN-100361977-C | 1-alkyl-3-aminoindazoles | ALCON INC (CH) | 2008-01-16 | — | — | CN | disclosed |
| EP-1578729-A4 | 1-ALKYL-3-AMINOINDAZOLES | ALCON INC (CH) | 2007-08-29 | — | — | EP | disclosed |
| US-20060079696-A1 | Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses | GENFIT (FR) | 2006-04-13 | — | — | US | disclosed |
| WO-2006035157-A2 | SUBSTITUTED N-(BENZYL)PHENYLACETAMIDE DERIVATIVE COMPOUNDS, PREPARATION METHOD THEREOF AND USES OF SAME AS PPAR LIGANDS IN THE TREATMENT OF LIPID AND/OR GLUCIDIC DISORDERS | GENFIT (FR) | 2006-04-06 | — | — | WO | disclosed |
| US-20060052613-A1 | 1-alkyl-3-aminoindazoles | ALCON, INC. (CH) | 2006-03-09 | — | — | US | disclosed |
| CN-1732157-A | 1-alkyl-3-aminoindazoles | ALCON INC (CH) | 2006-02-08 | — | — | CN | disclosed |
| EP-1578729-A1 | 1-ALKYL-3-AMINOINDAZOLES | Alcon, Inc. (CH) | 2005-09-28 | — | — | EP | disclosed |
| WO-2004058725-A1 | 1-ALKYL-3-AMINOINDAZOLES | ALCON, INC. (CH) | 2004-07-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190241540-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | CRY1, CRY2, HCCS | KDM4E 1254/4885HSD17B10 1044/4885HPGD 2050/4885 |
| US-20060079696-A1 | Substituted compounds derived from N-(benzyl)phenylacetamide, preparation and uses | AADAC, NAT1, PARN | KDM4E 2470/4885HSD17B10 3633/4885HPGD 817/4885 |
| US-20060052613-A1 | 1-alkyl-3-aminoindazoles | NAT1, AADAC, CYP1B1 | KDM4E 2238/4885HSD17B10 961/4885HPGD 136/4885 |
| US-20210171495-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | CRY1, CRY2, HCCS | KDM4E 1254/4885HSD17B10 1044/4885HPGD 2050/4885 |
| US-10759777-B2 | Carbazole-containing amides, carbamates, and ureas as cryptochrome modulators | CRY1, CRY2, HCCS | KDM4E 1254/4885HSD17B10 1044/4885HPGD 2050/4885 |
| US-20220411399-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | CRY1, CRY2, HCCS | KDM4E 1254/4885HSD17B10 1044/4885HPGD 2050/4885 |
| US-20110313158-A1 | Two Component Recyclable Heterogeneous Catalyst, Process for Preparation Thereof and its Use for Preparation of Amines | HCN2, RAC2, HCN1 | KDM4E 2112/4885HSD17B10 1800/4885HPGD 2141/4885 |
| US-20090149659-A1 | 1-ALKYL-3-AMINOINDAZOLES | NAT1, AADAC, CYP1B1 | KDM4E 2238/4885HSD17B10 961/4885HPGD 136/4885 |
| US-20240190837-A1 | CARBAZOLE-CONTAINING AMIDES, CARBAMATES, AND UREAS AS CRYPTOCHROME MODULATORS | CRY1, CRY2, HCCS | KDM4E 1254/4885HSD17B10 1044/4885HPGD 2050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.