Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 5/20 | 0.53 |
| ▸ | CA2 | P00918 | 5/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.52 |
| ▸ | CA9 | Q16790 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8212594 | 0.90 | PIK3CA (0.49) | PIK3CDPIK3CAPOLBMTOR | |
| SCHEMBL8097366 | 0.84 | PIK3CD (0.47) | PIK3CDPIK3CALMNAKDM4ENPC1 | |
| SCHEMBL8214217 | 0.80 | CA12 (0.46) | CA1CA2CA12PIK3CDPIK3CA | |
| SCHEMBL737935 | 0.79 | PIK3CA (0.84) | PIK3CDPIK3CAMTOR | |
| SCHEMBL8091771 | 0.79 | PIK3CD (0.51) | CA1CA2CA12PIK3CDPIK3CA | |
| SCHEMBL8216529 | 0.79 | PIK3CD (0.53) | PIK3CDPIK3CAMEN1KMT2AMTOR | |
| SCHEMBL8206578 | 0.78 | PIK3CD (0.46) | PIK3CDPIK3CALMNAKDM4EALDH1A1 | |
| SCHEMBL8215180 | 0.78 | NAMPT (0.46) | PIK3CDPIK3CAPOLBMTOR | |
| SCHEMBL8214526 | 0.78 | PIK3CD (0.61) | PIK3CDPIK3CAMTOR | |
| SCHEMBL8214032 | 0.78 | ATM (0.45) | CA1CA2CA12PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007750-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |