Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 5/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8215180 | 0.90 | NAMPT (0.46) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL8213062 | 0.88 | PIK3CD (0.49) | PIK3CAMTORPIK3CGL3MBTL1KDM4E | |
| SCHEMBL8214019 | 0.88 | ATM (0.45) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL8212594 | 0.87 | PIK3CA (0.49) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL8214031 | 0.85 | ALDH1A1 (0.46) | PIK3CAMTORPIK3CGKDM4ECA12 | |
| SCHEMBL8215294 | 0.83 | NAMPT (0.42) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL11925440 | 0.81 | CA2 (0.42) | PIK3CAMTORCA12CA1CA2 | |
| SCHEMBL8213054 | 0.81 | PIK3CA (0.48) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL8204518 | 0.81 | PIK3CA (0.46) | ATMPIK3CAMTORPIK3CGPOLB | |
| SCHEMBL8083924 | 0.81 | PIK3CA (0.44) | ATMPIK3CAMTORPIK3CGL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2057140-B1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2012-08-08 | — | — | EP | disclosed |
| WO-2008023159-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | WO | disclosed |