Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 9/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8214220 | 0.88 | PIK3CA (0.48) | PIK3CDPIK3CAALDH1A1MEN1KMT2A | |
| SCHEMBL8206578 | 0.85 | PIK3CD (0.46) | PIK3CDPIK3CAALDH1A1MEN1KMT2A | |
| SCHEMBL1755698 | 0.85 | ALDH1A1 (0.43) | PIK3CAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8095121 | 0.85 | PIK3CD (0.43) | PIK3CDPIK3CAALDH1A1L3MBTL1MEN1 | |
| SCHEMBL8095008 | 0.84 | CA1 (0.53) | PIK3CDPIK3CAALDH1A1MEN1KMT2A | |
| SCHEMBL8214217 | 0.82 | CA12 (0.46) | PIK3CDPIK3CAALDH1A1MEN1KMT2A | |
| SCHEMBL8214158 | 0.82 | PTGS2 (0.44) | PIK3CDPIK3CAALDH1A1MEN1KMT2A | |
| SCHEMBL8213776 | 0.81 | CA12 (0.48) | PIK3CDPIK3CAMAPTCYP3A4GAA | |
| SCHEMBL8214526 | 0.81 | PIK3CD (0.61) | PIK3CDPIK3CA | |
| SCHEMBL8216529 | 0.79 | PIK3CD (0.53) | PIK3CDPIK3CAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007750-A1 | MORPHOLINO PYRIMIDINE DERIVATIVES USED IN DISEASES LINKED TO MTOR KINASE AND/OR PI3K | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |