SCHEMBL809573

SCHEMBL809573

FC(F)(c1ccc(Cl)cc1)C(F)(F)c1ccc(Oc2ccc(C(F)(F)C(F)(F)c3ccc(Cl)cc3)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 1/20 0.52
MAOB P27338 1/20 0.52
AR P10275 1/20 0.46
HTR2A P28223 1/20 0.44
SLC6A4 P31645 1/20 0.44
KCNH2 Q12809 1/20 0.44
CYP19A1 P11511 1/20 0.39
LTA4H P09960 5/20 0.39
ALDH1A1 P00352 3/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
MAPT P10636 2/20 0.38
HPGD P15428 2/20 0.38
KDM4E B2RXH2 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP2D6 P10635 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAPK1 P28482 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3672112 0.91 MAOA (0.48) MAOAMAOBARHTR2ASLC6A4
SCHEMBL3679183 0.91 MAOA (0.48) MAOAMAOBARHTR2ASLC6A4
SCHEMBL3679587 0.90 MAOA (0.47) MAOAMAOBARHTR2ASLC6A4
SCHEMBL5401000 0.85 LMNA (0.50) CYP19A1MEN1KMT2AMAPK1TSHR
SCHEMBL3676084 0.81 AR (0.43) ARKCNH2CYP19A1ALDH1A1MEN1
SCHEMBL457634 0.80 MAOA (0.74) MAOAMAOBLTA4HALDH1A1MEN1
SCHEMBL9242729 0.80 MAOA (0.74) MAOAMAOBLTA4HALDH1A1MEN1
SCHEMBL21501228 0.79 MAOA (0.45) MAOAMAOBARHTR2ASLC6A4
SCHEMBL3671300 0.79 APP (0.40) LTA4HALDH1A1MEN1KMT2AMAPT
SCHEMBL16626263 0.78 CYP19A1 (0.50) KCNH2CYP19A1ALDH1A1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1693405-B1 PROTON CONDUCTING MEMBRANE AND PROCESS FOR PRODUCING THE SAME JSR CORP (JP) 2012-05-02 EP disclosed
EP-1845122-B1 POLYARYLENE, PROCESS FOR PRODUCING THE SAME, SOLID POLYELECTROLYTE, AND PROTON-CONDUCTIVE FILM JSR CORP (JP) 2011-11-16 EP disclosed
US-8058365-B2 Proton conducting membrane and process for producing the same JSR CORPORATION (JP) 2011-11-15 US disclosed
US-8039165-B2 Proton conductive membrane comprising a copolymer JSR CORPORATION (JP) 2011-10-18 US disclosed
US-7981566-B2 Membrane electrode assembly and polymer electrolyte fuel cell therewith HONDA MOTOR CO., LTD. (JP) 2011-07-19 US disclosed
US-7893303-B2 Polyarylene, process for producing the same, solid polyelectrolyte, and proton-conductive film JSR CORPORATION (JP) 2011-02-22 US disclosed
EP-1479714-B1 Membrane-electrode assembly for direct methanol type fuel cell and proton conductive membrane JSR CORP (JP) 2010-12-22 EP disclosed
US-20100190088-A1 MEMBRANE ELECTRODE ASSEMBLY AND POLYMER ELECTROLYTE FUEL CELL THEREWITH HONDA MOTOR CO., LTD. (JP) 2010-07-29 US disclosed
US-7727652-B2 Membrane electrode assembly and polymer electrolyte fuel cell therewith HONDA MOTOR CO., LTD. (JP) 2010-06-01 US disclosed
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
US-20040028806-A1 Process for producing electrolyte membrane-bonded electrode and varnish composition used therein THE RELIABLE AUTOMATIC SPRINKLER CO. INC. 2004-02-12 US disclosed
US-6685984-B2 FORMING FUEL CELL COMPRISED OF NONPENETRATING ELECTROLYTE MEMBRANE ON ELECTRODE JSR CORPORATION (JP) 2004-02-03 US disclosed
US-20030228421-A1 Method for the production of multilayers JSR CORPORATION 2003-12-11 US disclosed
US-20030195301-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2003-10-16 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed
US-6555626-B2 Controlled amount of sulfonic acid groups; copolymer of an aromatic compound having a main chain containing electron withdrawing groups and aromatic compounds with no electron withdrawing groups; durability, strength, conductivity JSR CORPORATION (JP) 2003-04-29 US disclosed
US-20020172850-A1 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA, JSR CORPORATION 2002-11-21 US disclosed
US-20010037000-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2001-11-01 US disclosed
EP-1138712-A2 Polyarylene copolymers and proton-conductive membrane JSR Corporation (JP) 2001-10-04 EP disclosed