Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.32 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.32 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8096703 | 1.00 | ADRA2A (0.34) | ADRA2ALMNASMN1; SMN2SLC6A2SLC6A4 | |
| SCHEMBL6952658 | 0.91 | ADRA2A (0.40) | ADRA2ABCHEACHE | |
| Fumaric Acid SCHEMBL8092830 | 0.87 | ADRA2A (0.36) | ADRA2ALMNA | |
| Fumaric Acid SCHEMBL8092823 | 0.87 | ADRA2A (0.36) | ADRA2ALMNA | |
| Fumaric Acid SCHEMBL8092419 | 0.85 | ADRA2A (0.50) | ADRA2A | |
| Fumaric Acid SCHEMBL8092413 | 0.85 | ADRA2A (0.50) | ADRA2A | |
| Fumaric Acid SCHEMBL8092586 | 0.85 | ADRA2A (0.50) | ADRA2AALDH1A1 | |
| Fumaric Acid SCHEMBL8092594 | 0.85 | ADRA2A (0.50) | ADRA2AALDH1A1 | |
| Fumaric Acid SCHEMBL8091870 | 0.80 | ADRA2A (0.46) | ADRA2ALMNA | |
| Fumaric Acid SCHEMBL8092403 | 0.80 | ADRA2A (0.46) | ADRA2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |