Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8092594 | 1.00 | ADRA2A (0.50) | ADRA2AALDH1A1 | |
| SCHEMBL6953678 | 0.90 | ADRA2A (0.59) | ADRA2A | |
| Fumaric Acid SCHEMBL8092413 | 0.90 | ADRA2A (0.50) | ADRA2A | |
| Fumaric Acid SCHEMBL8092419 | 0.90 | ADRA2A (0.50) | ADRA2A | |
| Fumaric Acid SCHEMBL8092830 | 0.88 | ADRA2A (0.36) | ADRA2A | |
| Fumaric Acid SCHEMBL8092823 | 0.88 | ADRA2A (0.36) | ADRA2A | |
| Fumaric Acid SCHEMBL8096703 | 0.85 | ADRA2A (0.34) | ADRA2AALDH1A1 | |
| Fumaric Acid SCHEMBL8096698 | 0.85 | ADRA2A (0.34) | ADRA2AALDH1A1 | |
| Fumaric Acid SCHEMBL8092398 | 0.83 | ADRA2A (0.46) | ADRA2A | |
| Fumaric Acid SCHEMBL8091878 | 0.83 | ADRA2A (0.46) | ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183907-C | Imidazoline compound, preparing process thereof and pharmaceutical composition contg. same | SERVIER LAB (FR) | 2005-01-12 | — | — | CN | disclosed |
| US-6127396-A | Imidazoline compounds | ADIR ET COMPAGNIE (FR) | 2000-10-03 | — | — | US | disclosed |