Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 7/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.45 |
| ▸ | KDM1A | O60341 | 3/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8097079 | 1.00 | MTNR1A (0.45) | MTNR1AMTNR1BKDM1AKCNH2KDM1B | |
| SCHEMBL8095899 | 0.86 | MTNR1A (0.44) | MTNR1AMTNR1BSLC6A2SLC6A4HTR2A | |
| SCHEMBL8095897 | 0.86 | MTNR1A (0.44) | MTNR1AMTNR1BSLC6A2SLC6A4HTR2A | |
| SCHEMBL8097504 | 0.81 | MTNR1B (0.50) | MTNR1AMTNR1BHTR2AHTR2CHTR2B | |
| SCHEMBL8097498 | 0.81 | MTNR1B (0.50) | MTNR1AMTNR1BHTR2AHTR2CHTR2B | |
| SCHEMBL8098175 | 0.81 | MTNR1B (0.51) | MTNR1AMTNR1BKDM1ASLC6A2SLC6A4 | |
| SCHEMBL8088842 | 0.81 | MTNR1B (0.51) | MTNR1AMTNR1BSLC6A2SLC6A4HTR2A | |
| SCHEMBL8098179 | 0.81 | MTNR1B (0.51) | MTNR1AMTNR1BKDM1ASLC6A2SLC6A4 | |
| SCHEMBL8088845 | 0.81 | MTNR1B (0.51) | MTNR1AMTNR1BSLC6A2SLC6A4HTR2A | |
| SCHEMBL8101397 | 0.77 | HTR2C (0.55) | MTNR1AMTNR1BHTR2AHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0747346-B1 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL MYERS SQUIBB CO (US) | 2000-02-16 | — | — | EP | disclosed |
| EP-0747346-A2 | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-12-11 | — | — | EP | disclosed |