Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 4/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104051 | 0.93 | NAMPT (0.38) | NAMPTPIK3CAMTORLMNAPIK3CD | |
| SCHEMBL8096186 | 0.92 | MAPT (0.41) | NAMPTPIK3CALMNAPIK3CDMAPT | |
| SCHEMBL8099812 | 0.91 | NAMPT (0.44) | NAMPTPIK3CAPIK3CDKDR | |
| SCHEMBL8099408 | 0.89 | CA2 (0.42) | NAMPTPIK3CAMTORALDH1A1PIK3CD | |
| SCHEMBL8083973 | 0.88 | ALDH1A1 (0.43) | NAMPTPIK3CAMTORALDH1A1PIK3CD | |
| SCHEMBL8097227 | 0.87 | PIK3CD (0.43) | NAMPTPIK3CALMNAPIK3CDKDR | |
| SCHEMBL8090391 | 0.86 | CA1 (0.41) | NAMPTPIK3CAMTORALDH1A1PIK3CD | |
| SCHEMBL8099845 | 0.86 | KDR (0.41) | NAMPTPIK3CALMNAPIK3CDKDR | |
| SCHEMBL8093145 | 0.85 | MAPT (0.39) | NAMPTPIK3CAMTORPIK3CDMAPT | |
| SCHEMBL8100146 | 0.85 | CA1 (0.41) | NAMPTPIK3CAMTORALDH1A1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009007748-A2 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES | ASTRAZENECA AB (SE) | 2009-01-15 | — | — | WO | disclosed |