Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.44 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 6/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1309773 | 0.88 | ALDH1A1 (0.48) | TRPA1ALDH1A1TSHRPDCD1CD274 | |
| SCHEMBL6448256 | 0.85 | TSHR (0.50) | TSHRPDCD1CD274LTB4R2PDK2 | |
| SCHEMBL10892045 | 0.83 | ALDH1A1 (0.57) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL809887 | 0.82 | DPP4 (0.64) | TRPA1ALDH1A1TSHRCES2CES1 | |
| SCHEMBL175541 | 0.80 | PTGS1 (0.50) | TSHRCES2CES1KMT2APTGER1 | |
| SCHEMBL6499360 | 0.80 | DPP4 (0.55) | PDCD1CD274LTB4R2PDK2DPP4 | |
| SCHEMBL3859896 | 0.79 | PDCD1 (0.47) | ALDH1A1TSHRPDCD1CD274LTB4R2 | |
| SCHEMBL7951583 | 0.79 | PDCD1 (0.61) | ALDH1A1PDCD1CD274LTB4R2PDK2 | |
| SCHEMBL10535771 | 0.79 | PDCD1 (0.45) | TRPA1ALDH1A1TSHRPDCD1CD274 | |
| SCHEMBL9023806 | 0.79 | ALDH1A1 (0.59) | TRPA1ALDH1A1TSHRCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968727-B2 | Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists | LEK PHARMACEUTICALS, D.D. (SI) | 2011-06-28 | — | — | US | claimed |
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | LEK PHARMACEUTICALS D.D. (SI) | 2009-12-24 | — | — | US | claimed |
| EP-1871764-A1 | A SYNTHESIS OF 4-BROMOMETHYL-2'-FORMYLBIPHENYL AND 4-BROMOMETHYL-2'- HYDROXYMETHYLBIPHENYL AND ITS USE IN PREPARATION OF ANGIOTENSIN II ANTAGONISTS | LEK Pharmaceuticals D.D. (SI) | 2008-01-02 | — | — | EP | claimed |
| WO-2006103068-A1 | A SYNTHESIS OF 4-BROMOMETHYL-2'-FORMYLBIPHENYL AND 4-BROMOMETHYL-2'- HYDROXYMETHYLBIPHENYL AND ITS USE IN PREPARATION OF ANGIOTENSIN II ANTAGONISTS | LEK PHARMACEUTICALS D.D. (SI) | 2006-10-05 | — | — | WO | claimed |
| US-7968727-B2 | Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists | LEK PHARMACEUTICALS, D.D. (SI) | 2011-06-28 | — | — | US | disclosed |
| US-7968727-B2 | Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists | LEK PHARMACEUTICALS, D.D. (SI) | 2011-06-28 | — | — | US | disclosed |
| US-7968727-B2 | Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists | LEK PHARMACEUTICALS, D.D. (SI) | 2011-06-28 | — | — | US | disclosed |
| US-7968727-B2 | Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists | LEK PHARMACEUTICALS, D.D. (SI) | 2011-06-28 | — | — | US | disclosed |
| US-7968727-B2 | Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists | LEK PHARMACEUTICALS, D.D. (SI) | 2011-06-28 | — | — | US | disclosed |
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | LEK PHARMACEUTICALS D.D. (SI) | 2009-12-24 | — | — | US | disclosed |
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | LEK PHARMACEUTICALS D.D. (SI) | 2009-12-24 | — | — | US | disclosed |
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | LEK PHARMACEUTICALS D.D. (SI) | 2009-12-24 | — | — | US | disclosed |
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | LEK PHARMACEUTICALS D.D. (SI) | 2009-12-24 | — | — | US | disclosed |
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | LEK PHARMACEUTICALS D.D. (SI) | 2009-12-24 | — | — | US | disclosed |
| EP-1871764-A1 | A SYNTHESIS OF 4-BROMOMETHYL-2'-FORMYLBIPHENYL AND 4-BROMOMETHYL-2'- HYDROXYMETHYLBIPHENYL AND ITS USE IN PREPARATION OF ANGIOTENSIN II ANTAGONISTS | LEK Pharmaceuticals D.D. (SI) | 2008-01-02 | — | — | EP | disclosed |
| EP-1871764-A1 | A SYNTHESIS OF 4-BROMOMETHYL-2'-FORMYLBIPHENYL AND 4-BROMOMETHYL-2'- HYDROXYMETHYLBIPHENYL AND ITS USE IN PREPARATION OF ANGIOTENSIN II ANTAGONISTS | LEK Pharmaceuticals D.D. (SI) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006103068-A1 | A SYNTHESIS OF 4-BROMOMETHYL-2'-FORMYLBIPHENYL AND 4-BROMOMETHYL-2'- HYDROXYMETHYLBIPHENYL AND ITS USE IN PREPARATION OF ANGIOTENSIN II ANTAGONISTS | LEK PHARMACEUTICALS D.D. (SI) | 2006-10-05 | — | — | WO | disclosed |
| WO-2006103068-A1 | A SYNTHESIS OF 4-BROMOMETHYL-2'-FORMYLBIPHENYL AND 4-BROMOMETHYL-2'- HYDROXYMETHYLBIPHENYL AND ITS USE IN PREPARATION OF ANGIOTENSIN II ANTAGONISTS | LEK PHARMACEUTICALS D.D. (SI) | 2006-10-05 | — | — | WO | disclosed |
| WO-2006103068-A1 | A SYNTHESIS OF 4-BROMOMETHYL-2'-FORMYLBIPHENYL AND 4-BROMOMETHYL-2'- HYDROXYMETHYLBIPHENYL AND ITS USE IN PREPARATION OF ANGIOTENSIN II ANTAGONISTS | LEK PHARMACEUTICALS D.D. (SI) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | GRK4, GRK2, GRK5 | TRPA1 1634/4885ALDH1A1 3706/4885TSHR 3662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.