Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.64 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | PNMT | P11086 | 2/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3789431 | 0.86 | DPP4 (0.72) | DPP4TAAR1CSNK2A1MAOBNOS3 | |
| SCHEMBL1309773 | 0.86 | ALDH1A1 (0.48) | DPP4TRPA1ALDH1A1TSHRMAOB | |
| SCHEMBL7791854 | 0.82 | DPP4 (0.67) | DPP4TSHRTAAR1CSNK2A1MAOB | |
| SCHEMBL809767 | 0.82 | TRPA1 (0.44) | DPP4TRPA1ALDH1A1TSHRCES2 | |
| SCHEMBL10892045 | 0.81 | ALDH1A1 (0.57) | DPP4TRPA1ALDH1A1TSHRTAAR1 | |
| SCHEMBL14034606 | 0.81 | DPP4 (0.64) | DPP4TAAR1CSNK2A1MAOBNOS3 | |
| SCHEMBL27689661 | 0.81 | DPP4 (0.64) | DPP4TAAR1CSNK2A1MAOBNOS3 | |
| SCHEMBL7142529 | 0.80 | DPP4 (0.69) | DPP4ALDH1A1TSHRTAAR1CSNK2A1 | |
| SCHEMBL2981250 | 0.79 | DPP4 (0.91) | DPP4ALDH1A1TAAR1CSNK2A1NOS3 | |
| SCHEMBL29872374 | 0.79 | DPP4 (1.00) | DPP4ALDH1A1TAAR1CSNK2A1PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968727-B2 | Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists | LEK PHARMACEUTICALS, D.D. (SI) | 2011-06-28 | — | — | US | disclosed |
| US-7968727-B2 | Synthesis of 4-bromomethyl-2′-formylbiphenyl and 4-bromomethyl-2′-hydroxymethylbiphenyl and its use in preparation of angiotensin II antagonists | LEK PHARMACEUTICALS, D.D. (SI) | 2011-06-28 | — | — | US | disclosed |
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | LEK PHARMACEUTICALS D.D. (SI) | 2009-12-24 | — | — | US | disclosed |
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | LEK PHARMACEUTICALS D.D. (SI) | 2009-12-24 | — | — | US | disclosed |
| WO-2006103068-A1 | A SYNTHESIS OF 4-BROMOMETHYL-2'-FORMYLBIPHENYL AND 4-BROMOMETHYL-2'- HYDROXYMETHYLBIPHENYL AND ITS USE IN PREPARATION OF ANGIOTENSIN II ANTAGONISTS | LEK PHARMACEUTICALS D.D. (SI) | 2006-10-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318521-A1 | Synthesis of 4-Bromomethyl-2'-Formylbiphenyl and 4-Bromomethyl-2'-Hydroxymethylbiphenyl and Its Use in Preparation of Giotensin II Antagonists | GRK4, GRK2, GRK5 | DPP4 838/4885TRPA1 1634/4885ALDH1A1 3706/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.