Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | IDH1 | O75874 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8094995 | 0.99 | LMNA (0.61) | LMNASLC2A1MEN1KMT2AHTT | |
| SCHEMBL8083369 | 0.87 | MEN1 (0.59) | LMNASLC2A1MEN1KMT2AHTT | |
| SCHEMBL8083234 | 0.86 | EPHX1 (0.62) | LMNASLC2A1MEN1KMT2AHTT | |
| SCHEMBL8083304 | 0.83 | ALDH1A1 (0.54) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL8091346 | 0.81 | ALDH1A1 (0.56) | LMNAMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL8091318 | 0.80 | TP53 (0.56) | MEN1KMT2AHTTSMN1; SMN2NPC1 | |
| SCHEMBL8091387 | 0.79 | KDR (0.68) | CA2 | |
| SCHEMBL20290535 | 0.78 | TSHR (0.51) | LMNASLC2A1MEN1KMT2AHTT | |
| SCHEMBL9341223 | 0.78 | NPC1 (0.48) | LMNASLC2A1MEN1KMT2AHTT | |
| SCHEMBL12530409 | 0.76 | MEN1 (0.79) | LMNASLC2A1MEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147115-A | SULFONYLUREIDO-4-HALOBENZENE DERIVATIVES; ANTICARCINOGENIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0467621-B1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | LILLY CO ELI (US) | 1994-06-15 | — | — | EP | disclosed |
| US-5216026-A | Administering to the mammal N-1-butanesulfonamide derivatives and salts | ELI LILLY AND COMPANY (US) | 1993-06-01 | — | — | US | disclosed |
| EP-0467621-A1 | N-phenyl-N'-alkylsulfonylureas, process for their preparation and antitumor compositions containing them | ELI LILLY AND COMPANY (US) | 1992-01-22 | — | — | EP | disclosed |