SCHEMBL809775

SCHEMBL809775

NC(c1ccccc1)C(NS(=O)(=O)c1ccc(Cl)c(Cl)c1)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SPPL2A Q8TCT8 8/20 0.47
PSEN1 P49768 6/20 0.47
PSEN2 P49810 6/20 0.47
APH1B Q8WW43 6/20 0.47
NCSTN Q92542 6/20 0.47
APH1A Q96BI3 6/20 0.47
PSENEN Q9NZ42 6/20 0.47
PTGES2 Q9H7Z7 2/20 0.46
PGR P06401 1/20 0.45
RAB9A P51151 1/20 0.43
SUMO3 P55854 1/20 0.43
SUMO2 P61956 1/20 0.43
SUMO1 P63165 1/20 0.43
NR3C1 P04150 1/20 0.42
CNR1 P21554 1/20 0.41
ACLY P53396 1/20 0.41
MAPT P10636 2/20 0.39
ALDH1A1 P00352 1/20 0.39
LMNA P02545 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15841410 0.84 SLC1A3 (0.51) MAPTALDH1A1LMNA
SCHEMBL2243560 0.84 SLC1A3 (0.51) MAPTALDH1A1LMNA
SCHEMBL2243565 0.84 SLC1A3 (0.51) MAPTALDH1A1LMNA
SCHEMBL810701 0.84 SLC1A3 (0.51) MAPTALDH1A1LMNA
SCHEMBL15841411 0.84 SLC1A3 (0.51) MAPTALDH1A1LMNA
SCHEMBL810250 0.83 SLC1A3 (0.56) PGRNR3C1CNR1ACLY
SCHEMBL3852094 0.82 GBA1 (0.51) ALDH1A1LMNA
SCHEMBL2067895 0.82 GBA1 (0.51) ALDH1A1LMNA
SCHEMBL3862569 0.82 GBA1 (0.51) ALDH1A1LMNA
SCHEMBL31702343 0.82 SLC1A3 (0.58) PGRMAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2399895-B1 Process for producing optically active aliphatic fluoroalcohol KANTO KAGAKU (JP) 2018-08-08 EP disclosed
US-8558033-B2 Process for producing optically active aliphatic fluoroalcohol KANTO KAGAKU KABUSHIKI KAISHA (JP) 2013-10-15 US disclosed
US-20110319671-A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE ALIPHATIC FLUOROALCOHOL KANTO KAGAKU KABUSHIKI KAISHA (JP) 2011-12-29 US disclosed
EP-2399895-A2 Process for producing optically active aliphatic fluoroalcohol Kanto Kagaku Kabushiki Kaisha (JP) 2011-12-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110319671-A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE ALIPHATIC FLUOROALCOHOL ADH1A, ADH1C, ADH5 SPPL2A 4281/4885PSEN1 4390/4885PSEN2 4713/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.