Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 12/20 | 0.51 |
| ▸ | HTR1D | P28221 | 9/20 | 0.51 |
| ▸ | HTR1B | P28222 | 9/20 | 0.51 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR2B | P41595 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 4/20 | 0.51 |
| ▸ | HTR5A | P47898 | 3/20 | 0.51 |
| ▸ | HTR1E | P28566 | 2/20 | 0.51 |
| ▸ | HTR1F | P30939 | 2/20 | 0.51 |
| ▸ | HTR3A | P46098 | 2/20 | 0.51 |
| ▸ | SLC47A1 | Q96FL8 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9264868 | 0.91 | HTR1A (0.48) | HTR2CCYP2D6HTR1AHTR1DHTR1B | |
| SCHEMBL10494700 | 0.87 | HTR1A (0.65) | HTR2CCYP2D6HTR1AHTR1DHTR1B | |
| SCHEMBL9765118 | 0.83 | HTR1A (0.74) | HTR2CCYP2D6HTR1AHTR1DHTR1B | |
| SCHEMBL10494776 | 0.83 | KDM4E (0.58) | HTR2CCYP2D6HTR1AHTR1DHTR1B | |
| SCHEMBL8092644 | 0.83 | HTR1D (0.74) | HTR2CCYP2D6HTR1AHTR1DHTR1B | |
| SCHEMBL10494796 | 0.81 | MPO (0.60) | HTR2CHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL16675461 | 0.81 | HTR2C (0.68) | HTR2CCYP2D6HTR1AHTR1DHTR1B | |
| SCHEMBL2791148 | 0.80 | HTR1A (0.74) | HTR2CCYP2D6HTR1AHTR1DHTR1B | |
| SCHEMBL10494772 | 0.80 | CSNK2A1 (0.56) | HTR2CHTR1AHTR1DHTR1BHTR2A | |
| Succinic Acid SCHEMBL5164498 | 0.79 | HTR1A (0.64) | HTR2CHTR1AHTR1DHTR1BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6025374-A | Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists | MERCK SHARP & DOHME, LTD. (GB) | 2000-02-15 | — | — | US | disclosed |