Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6762680 | 0.79 | VDR (0.46) | KDM4ECYP2D6ALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL9767627 | 0.77 | GAA (0.46) | ESR1ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL4669222 | 0.76 | CYP2D6 (0.53) | KDM4EPOLBCYP2D6ALDH1A1SLC22A2 | |
| SCHEMBL491994 | 0.74 | VDR (0.45) | KDM4ECYP2D6ALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL11988007 | 0.74 | VDR (0.45) | KDM4ECYP2D6ALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL5268174 | 0.73 | ESR1 (0.75) | KDM4EPOLBESR1CYP2D6SLC22A2 | |
| SCHEMBL890642 | 0.73 | GAA (0.50) | ESR1ALDH1A1CYP2C19CYP3A4CYP2C9 | |
| SCHEMBL8861461 | 0.73 | GAA (0.42) | ESR1CYP2D6ALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL9475352 | 0.73 | VDR (0.46) | KDM4ECYP2D6ALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL5145353 | 0.72 | HTT (0.50) | KDM4EESR1CYP2D6ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0983222-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 2000-03-08 | — | — | EP | disclosed |
| WO-1998052898-A9 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORP (CA) | 1999-04-01 | — | — | WO | disclosed |
| WO-1998052898-A1 | PHARMACEUTICAL AGENTS FOR THE TREATMENT OF CEREBRAL AMYLOIDOSIS | NYMOX CORPORATION (CA) | 1998-11-26 | — | — | WO | disclosed |